Laboratory biosafety manual 2012

Manual on collection, storage, and transport of specimens for tb testing producing reliable test results does not rely solely on the right performance of the stepbystep procedures of the test itself. Who mycobacteriology biosafety manual 2012 handbook on tb laboratory diagnostic methods for european union2018 efficacy and safety of delamanid in combination with an optimised background regimen for treatment of multidrugresistant tuberculosis. A spill of any quantity involving an agent infectious to humans, plants, or animals occurs in a public area. Emmett barkley, howard hughes medical institute, chevy chase, md, usa dr murray l.

Jul 18, 2019 the who laboratory biosafety manual 4th edition. Guidelines for laboratory facility certification part ii. Veiligheid bij het kweken van mycobacterium tuberculosis in. Laboratory biosafety manual were published in 1993 and 2004 respectively 2,3. Who laboratory biosafety manual updates absa conference. We promote biological safety at the nih through a broad range of. Who laboratory biosafety manual having served for global biosafety community hereinafter, who manual for more than 20 30 years, since it was first published in 1983, the laboratory biosafety manual has provided practical guidance on biosafety techniques for use in laboratories at all levels. The biosafety manual is not a replacement or substitute for a general laboratory safety manual, which covers other occupational hazards in the laboratory.

Biosafety and biosecurity in the veterinary microb iology laboratory and animal facilities 18 oie terrestrial manual 2012 v the statutory confinement of diseased, infected and incontact animals is necessary. Laboratory safety nanomaterials, schools, hazard analysis. Wcln resources wisconsin state laboratory of hygiene. Cohen, centers for disease control and prevention, atlanta, ga, usa. Guidelines for laboratory facility commissioning 8. As needed, an adhoc committee may be formed to consider policy implications for the university of emerging technologies and processes that have a biosafety component. University of illinois at chicago uicehso 2012 biological safety program manual page 81 of 96 called paraformaldehyde. The purpose of this manual is to define the biological safety policies and procedures pertaining to research operations at boston university and boston medical center.

The international cartagena protocol on biosafety deals primarily with the agricultural definition but many advocacy groups seek to expand it to include postgenetic threats. Guidance documents manuals ebsa european biosafety. Laboratory biosafety and biosecurity risk assessment. The challenge for managers of tb programmes and staff at laboratories, particularly in resourcelimited settings, has been to interpret the generic riskgroup.

Good microbiological technique and appropriate use of biosafety equipment by well trained staff remain the fundamental elements of laboratory biosafety. Laboratory guidelines research institute for tropical medicine. In 2007 a code of conduct for biosecurity has been proposed by the royal netherlands academy of arts and sciences to the scientific community. A manual of written standard operating procedures sops for the laboratory, in combination with this manual and the cdcnih publications biosafety in microbiological and biomedical laboratories, 5th edition and guidelines for research involving recombinant or synthetic nucleic acid molecules, provide general requirements for working with biological agents. Manual this manual does not address chemical, physical andor radiation hazards that are commonly encountered in a laboratory setting and is to be regarded as an addendum to the unbc chemical laboratory safety and methodology manual. Biosafety level 4 laboratory also known as the maximum containment laboratory, is specially designed for the handling of microorganisms in risk group 4. Receive training in standard microbiological techniques. Laboratory biosafety is the process of applying a combination of administrative controls, containment. The who tuberculosis laboratory biosafety manual 2012 incorporated a risk assessment approach that considered the procedures being performed. Sample laboratory biosafety manual for microbiological. The manual now covers risk assessment and safe use of recombinant dna technology, and provides guidelines for the comissioning and.

Laboratory biosafety manual third edition, 2004 pdf, 1. Anno 201220 was deze nieuwe richtlijn nog steeds niet gereed. We promote biological safety at the nih through a broad range of support services, consultation and assistance. The canadian biosafety handbook cbh, 2 nd edition, 2016 is intended as a companion document to the canadian biosafety standard cbs, 2 nd edition, 2015.

Biosafety manual oklahoma state universitystillwater. For this new edition, the manual has been extensively revised and expanded. Biosafety manual and standard operating procedures. Cdc biosafety in microbiological and biomedical laboratories bmbl 5th edition, cdc, u. The challenge for managers of tb programmes and staff at laboratories, particularly in resourcelimited. Sample laboratory biosafety manual for microbiological activities. In 2006 the who issued a biorisk management document entitled laboratory biosecurity guidance as a complement of laboratory biosafety manual 3 rd edition who, 2006. Its primary focus should be to provide pertinent information to help execute the operations of the lab in a safe and professional manner. Biosafety levels 1 laboratory safety and management. Major revisions to the 2014 institutional laboratory. The laboratory biosafety manual should be a living, working document that is an important resource for personnel engaged in the activities using biological and or rdna materials. Risk assessment and the classification of tb laboratories.

Laboratory biosafety levels unc gillings school of. The fourtier classification system of biosafety levels 14 described in whos laboratory biosafety manual2 provides broad guidance on basic concepts of biosafety for the development of national and international codes of practice. This manual describes the minimum biosafety measures that should be implemented at the different levels of. Pdf tuberculosis laboratory biosafety manual lasinrang. Laboratory biosafety is the process of applying a combination of administrative controls, containment principles, practices and procedures, safety equipment, emergency preparedness, and facilities to enable laboratory staff to work safely with potentially infectious microorganisms. Tuberculosis laboratory biosafety manual challenge tb. The biosafety level bsl is a description of the degree of physical containment being employed to confine biohazardous material within a laboratory or facility and to reduce the potential for exposure of laboratory workers, persons outside of the laboratory, and the environment. Tuberculosis laboratory biosafety manual ncbi bookshelf. A biosafety level bsl, or pathogenprotection level, is a set of biocontainment precautions required to isolate dangerous biological agents in an enclosed laboratory facility. The development of this fourth edition of the laboratory biosafety manual has. Guidelines for laboratoryfacility certification part ii. Resources for wcln laboratories wisconsin state laboratory. Performing a risk assessment laboratory biosafety manual, 3rd edition, 2004 link to world health organization website guidelines for safe work practices in human and animal medical diagnostic laboratories link to cdc website.

The ibc advocates the use of biosafety precautions that effectively reduce or. The laboratory safety group within the environmental health and safety office ehs has developed the biological safety manual to provide guidance on the safe handling of biological materials, safety practices to minimize the risk of exposure to potentially infectious materials, and procedures for. Who guidance on regulations for the transport of infectious substances, 20 2014 whohsegcr 2012. O four biological risk groups list of illustrations 1. Laboratory biosafety manual third edition for more than 20 years, since it was first published in 1983, the laboratory biosafety manual has provided practical guidance on biosafety techniques for use in laboratories at all levels. The fourtier classification system of biosafety levels 14 described in whos laboratory biosafety manual 2 provides broad guidance on basic concepts of biosafety for the development of national and international codes of practice. A laboratory acquired infection is known or suspected, or b. University of illinois at chicago uicehso 2012 biological safety program manual page 30 of 96 materials such as autoclave tape, must be used with each load. Pdf feasibility of establishing a biosafety level 3.

The primary purpose of the biosafety manual is to provide an appropriate training and reference tool relative to biosafety for laboratory staff, as discussed in the ehs sop, biosafety training. The who has issued a request for feedback on the new fourth edition of the who laboratory biosafety manual lbm. Laboratory safety the handbook global edition stop tb. Laboratory guidelines research institute for tropical. The levels of containment range from the lowest biosafety level 1 bsl1 to the highest at level 4 bsl4. This biosafety manual is applicable to all laboratory, research, teaching, service, and support activities that may involveexposure to biohazard agents or materials ous or otherwisecomes under the purview of the institutional biosafety committee ibc at the university of montana. The development of this third edition of the laboratory biosafety manual has been made possible through the contributions of the following, whose expertise is gratefully acknowledged. The practices and procedures in the laboratory are required for work with dangerous agents which cause life. In 2007 a code of conduct for biosecurity has been proposed by the royal netherlands academy of. In the united states, the centers for disease control and prevention cdc have specified these levels. It all starts in the acceptance of correct, adequate and quality specimens brought to the laboratory.

Foreword this reference manual outlines the safe use, storage, handling, waste disposal and emergency management of biohazardous materials for the university of northern british columbia unbc. The goals of the biological safety program, referenced in this manual as the biosafety program, are to protect laboratory workers, the public, and the environment from potentially hazardous biological agents. It is intended to inform rather than replace countrylevel requirements and standards for biosafety. The maximum containment laboratory biosafety level 4 6. Tuberculosis laboratory biosafety manual vii abbreviations ach air. These may react with organic materials such as paper.